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FLT3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 210491AP

Catalog No. 50-173-3228


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Description

Description

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Specifications

Specifications

FLT3
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P36888, Q00342
CD135, FL cytokine receptor, FLK2, FLT 3, FLT3, Fms like tyrosine kinase 3, fms related tyrosine kinase 3, Stem cell tyrosine kinase 1, STK 1, STK1
Rabbit
IgG
150 μL
-20°C
Primary
140635, 14255, 2322
Immunoprecipitation, Western Blot
Unconjugated
FLT3
Liquid
Flt3
FLT3 Fusion Protein Ag15391
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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