FMO1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA593278

Catalog No. PIPA593278

Description

Immunogen sequence: KPTLAIIGLI KPLGSMIPTG ETQARWAVRV LKGVNKLPPP SVMIEEINAR KENKPSWFGL CYCKALQSDY ITYIDELLTY INAKPNLFSM LLTDPHLALT VFFGPCSPYQ FRLTGPGKWE GARNAIMTQW DRTFKVIKAR VVQESPSPFE SFLKVFSFLA LLVAIFLIFL; Positive Samples: Mouse liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Specifications

• Antigen: FMO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FMO1
• Gene Symbols: Fmo1
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 363-532 of human FMO1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunofluorescence, Western Blot
• Concentration: 3.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P50285, Q01740
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14261, 2326
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid