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FMO3 Mouse anti-Human, Clone: OTI3H1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526970

Catalog No. PIMA526970


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Description

Description

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
Specifications

Specifications

FMO3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P31513
Dimethylaniline monooxygenase [N oxide forming] 3;Dimethylaniline monooxygenase [N-oxide-forming] 3;Dimethylaniline monooxygenase 3;Dimethylaniline oxidase 3;dJ127D3.1;Flavin containing monooxygenase 3;FMO 3;FMO form 2;FMO II;FMO3;FMO3_HUMAN;FMOII;Hepatic flavin containing monooxygenase 3;Hepatic flavin-containing monooxygenase 3;MGC34400;TMAU;Trimethylamine monooxygenase;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2328
Immunohistochemistry (Paraffin), Western Blot
OTI3H1
Unconjugated
FMO3
Liquid
FMO3
Human recombit protein fragment corresponding to amino acids 1-291 of FMO3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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