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FOLR3 Mouse anti-Human, Clone: OTI6C1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527489

Catalog No. PIMA527489


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Description

Description

Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma ft. (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in maligt tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
Specifications

Specifications

FOLR3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P41439
Folate receptor gamma, FR-gamma, FR- gamma, FR gamma, Folate receptor 3, FOLR3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2352
Immunohistochemistry (Paraffin), Western Blot
OTI6C1
Unconjugated
FOLR3
Liquid
FOLR3
Full length human recombit protein of FOLR3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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