FOS Mouse anti-Human, Clone: OTI7D6, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF806977
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOFBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
|Full length human recombit protein of human FOS produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|AP-1, C-FOS, p55|
|-20° C, Avoid Freeze/Thaw Cycles|
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