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  6. 184050U

Fostriecin sodium salt, Tocris Bioscience™

Catalog Number 184050u
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Quantity:
50 μg
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87860-39-7
C19H26NaO9P
452.372
XBUIKNRVGYFSHL-SOAGNPLSSA-M
fostriecin sodium salt
124080892
sodium;[(1Z,3R,4R,6R,7E,9E,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate
CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
This item is not returnable. View return policy
87860-39-7
C19H26NaO9P
452.372
XBUIKNRVGYFSHL-SOAGNPLSSA-M
fostriecin sodium salt
124080892
sodium;[(1Z,3R,4R,6R,7E,9E,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate
CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]

Description

Potent PP2A and PP4 inhibitor

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.
Quantity 50 μg
Formula Weight 452.37
Percent Purity >98%
Chemical Name or Material Fostriecin sodium salt

Safety and Handling

Recommended Storage Desiccate at -20°C
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