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FOXL2 Rabbit anti-Human, Unconjugated, Polyclonal, Active Motif™

Rabbit Polyclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 61283

Encompass

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Catalog No. 50-199-3299


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Description

Description

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.
Specifications

Specifications

FOXL2
Western Blot
Unconjugated
FOXL2
Liquid
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
668
FOXL2
Lot-Specific
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
P58012
AU045128; Blepharophimosis; BOS_1244; BPES; BPES1; epicanthus inversus; forkhead box L2; Forkhead box protein L2; forkhead transcription factor FOXL2; forkhead transcription factor L2; Foxl2; LUSTR2; MGC14393; Pfrk; P-Frk; PINTO; Pituitary forkhead factor; POF3; putative transcription factor foxl2
This FOXL2 antibody was raised against a peptide within the N-terminal region of human FOXL2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
SDS
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