Selective ERK inhibitor (IC50 values are 0.14 and 0.31µM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10µM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30µM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1µM).
Chemical Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
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