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Fra2 Mouse anti-Human, Rat, Clone: OTI7E4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527193

Catalog No. PIMA527193


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Description

Description

Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2. Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the  ft.leucine-zipper ft. motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Specifications

Specifications

Fra2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P15408, P51145
FRA2, FRA-2, fos-related antigen 2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2355, 25446
Western Blot
OTI7E4
Unconjugated
FOSL2
Liquid
FOSL2
Human recombit protein fragment corresponding to amino acids 110-326 of FOSL2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Rat
Documents
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