Tocris FRAX 486
Potent p21-activated kinase (PAK) inhibitor; brain penetrant and orally bioavailable
Manufacturer: Tocris 5190/50
DescriptionPotent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.
- Chemical Name: 6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
- Formula: C25H23Cl2FN6O
- CAS Number: 1232030-35-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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