FSHR Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550963
FSH Receptor / FSHR Polyclonal Antibody detects endogenous levels of FSH Receptor / FSHR protein.Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This ""turn-off"" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
|Synthesized peptide derived from the Internal region of human FSHR.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4|
|P23945, P35378, P20395|
|Follicle Stimulating Hormone Receptor, FSH-R, Follitropin Receptor|
|-20° C, Avoid Freeze/Thaw Cycles|
|14309, 2492, 25449|
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