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FTI 277, Tocris Bioscience™

Catalog Number 24071
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Quantity:
1 mg
This item is not returnable. View return policy
1217447-06-7
C24H30F3N3O5S2
561.635
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
fti-277 trifluoroacetate salt, n-4-2 r-amino-3-mercaptopropyl amino-2-phenylbenzoyl methionine methyl ester trifluoroacetate salt, fti-277 trifluoroacetate, fti-277 trifluoroacetate salt hplc , amorphous semi-solid
71311821
methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;2,2,2-trifluoroacetic acid
COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
This item is not returnable. View return policy
1217447-06-7
C24H30F3N3O5S2
561.635
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
fti-277 trifluoroacetate salt, n-4-2 r-amino-3-mercaptopropyl amino-2-phenylbenzoyl methionine methyl ester trifluoroacetate salt, fti-277 trifluoroacetate, fti-277 trifluoroacetate salt hplc , amorphous semi-solid
71311821
methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;2,2,2-trifluoroacetic acid
COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O

Description

Prodrug form of FTI 276 (Cat. No. 2406)

Prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Quantity 1 mg
Formula Weight 561.64
Percent Purity >95%
Chemical Name or Material FTI 277

Safety and Handling

Recommended Storage Store at -80°C
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