Furin Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS13228R

Catalog No. 50-198-2720

Description

Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ˜10 kDa amino-terminal proregion, a highly conserved ˜55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.

Specifications

• Antigen: Furin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FURIN
• Gene Alias: 9130404I01Rik; dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; FUR; FURIN; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; furin, paired basic amino acid cleaving enzyme; PACE; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; Paired basic amino acid residue-cleaving enzyme; Pcsk3; Prohormone convertase 3; proprotein convertase subtilisin/kexin type 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3; SPC1; subtilisin pro-protein processing enzyme
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5045
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P09958
• Gene Symbols: FURIN
• Immunogen: KLH conjugated synthetic peptide derived from human Furin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG