FXR Mouse anti-Human, Clone: OTI4F12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527121
DescriptionThe steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|BAR, FXR, HRR-1, HRR1, RIP14, RXR-interacting protein 14, bile acid receptor, farnesoid X nuclear receptor, farnesoid X-activated receptor, farnesol receptor HRR-1, retinoid X receptor-interacting protein 14|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 21-297 of NR1H4 produced in E.coli|
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