FZD6 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 720414
This antibody is predicted to react with Monkey, Horse, Rabbit.FZD6 is a member of the ′frizzled′ gene family, which encodes 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. FZD6 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains. However, unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis.
|Protein corresponding to human FZD6 [aa19-aa201]|
|PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.4|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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