FZD8 Rabbit anti-Human, Unconjugated, Clone: JB40-16, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA534703
Positive Control: Mouse lung tissue lysates, Human kidney tissue, human uterus tissue.Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
|Immunohistochemistry (Paraffin), Western Blot|
|TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4|
|Frizzled-8; Fz8; Fz-8; Fzd8; hFZ8; HGNC:4046|
|-20°C, Avoid Freeze/Thaw Cycles, store in dark|