Invitrogen™ GAB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 720334

Catalog No. PI720334

Description

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature. This antibody is predicted to react with Monkey, Cat, Bovine and Sheep.

Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet-derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGF), as well as in response to cell-cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3-kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.

Specifications

• Antigen: GAB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GAB1
• Gene Alias: AA408973; AW107238; EGK_16125; GAB1; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2549, 700367
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q13480
• Gene Symbols: GAB1
• Immunogen: Peptides corresponding to Human GAB1 (aa 524-541, 675-694).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rhesus Macaque
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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