Invitrogen™ GAB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588958

Catalog No. PIPA588958

Description

Immunogen sequence: ENSRSVAATI PRRNTLPAMD NSRLHRASSC ETYEYPQRGG ESAGRSAESM SDGVGSFLPG KMIVGRSDST NSEDNYVPMN PGSSTLLAME RAGDNSQSVY IPMSPGAHHF DSLGYPSTTL PVHRGPSRGS EIQPPPVNRN LKPDRKAKPT PLDLRNNTVI DELPFKSPIT KSWSRANHTF NSSSSQYCRP ISTQSITSTD SGDSEENYVP MQNPVSASPV PSGTNSPAPK KSTGSVDYLA LDFQPSSPSP HRKPSTSSVT SDEKVDYVQV DKEKTQALQN TMQEWTDVRQ SSEPSKGAKL; Positive Samples: HeLa, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm.

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Specifications

• Antigen: GAB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GAB2
• Gene Alias: AI463667; D130058I17Rik; GAB2; Grb2 associated binder 2; GRB2 associated binding protein 2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; p97; PH domain-containing adaptor molecule p97; pp100
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14389, 9846
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.37 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9UQC2, Q9Z1S8
• Gene Symbols: GAB2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_5367391).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG