GABRA1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585763

Catalog No. PIPA585763

Description

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Rabbit (100%), Chicken (88%), Rhesus Monkey (100%), Bovine (100%). Positive Control: mouse brain, rat brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.

Specifications

• Antigen: GABRA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GABRA1
• Gene Alias: ECA4, EIEE19, EJM, EJM5, GABA alpha subunit, GABA(A) receptor subunit alpha-1, GABA(A) receptor, alpha 1, GABAA alpha 1, GABAAR alpha1, GABRA 1, GABRA1, Gabra-1, gamma-aminobutyric acid, gamma-aminobutyric acid A receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1, gamma-aminobutyric acid A receptor alpha 1 variant 1, gamma-aminobutyric acid A receptor alpha 1 variant 2, gamma-aminobutyric acid A receptor alpha 1 variant 3, gamma-aminobutyric acid A receptor alpha 1 variant 4, gamma-aminobutyric acid A receptor, alpha 1, gamma-aminobutyric acid receptor subunit alpha-1, gamma-aminobutyric acid receptor subunit alpha-1-like, gamma-aminobutyric acid type A receptor alpha1 subunit, gamma-aminobutyric acid type A receptor subunit alpha1, LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14394, 29705
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.75 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P62812, P62813
• Gene Symbols: GABRA1
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of mouse GABA A Receptor alpha 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov