GAD67 Mouse anti-Human, Non-human primate, Clone: OTI3G9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524909
DescriptionGAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predomit GAD-67 form and the minor GAD-25 form.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|GAD1; glutamate decarboxylase 1 (brain, 67kDa); FLJ45882; GAD; SCP; OTTHUMP00000041055; glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kD); GAD67; GAD25|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Full length human recombit protein of GAD1 produced in HEK293T cell|
|Human, Non-human primate|
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