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GAD67 Mouse anti-Human, Non-human primate, Clone: OTI3G9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524909

Catalog No. PIMA524909


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Description

Description

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predomit GAD-67 form and the minor GAD-25 form.
Specifications

Specifications

GAD67
Monoclonal
0.45 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q99259
GAD1; glutamate decarboxylase 1 (brain, 67kDa); FLJ45882; GAD; SCP; OTTHUMP00000041055; glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kD); GAD67; GAD25
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2571, 613030
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
OTI3G9
Unconjugated
GAD1
Liquid
GAD1
Full length human recombit protein of GAD1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate
Documents
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