Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Tocris™ Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Manufacturer:  Tocris™ 3590/10

 View more versions of this product

Catalog No. 35-901-0R


  Check Availability
Add to cart

Disclaimers:

For Research Use Only


Specifications

Description

Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC50 value of 0.78 - 1.64µM and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79µM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks Kir2.1 channels (EC50 ≤ 100nM).
  • Chemical Name: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
  • Formula: C38H44O8
  • CAS Number: 2752-65-0
  • Solubility: Soluble to 75mM in DMSO and to 100mM in ethanol
Description & Specifications

Specifications

Gambogic acid
Gambogic acid
628.75
10mg
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit