Tocris™ Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Manufacturer: Tocris™ 3590/10

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Catalog No. 35-901-0R

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For Research Use Only


    Product Type Gambogic acid
    Inhibitors Gambogic acid
    Molecular Weight 628.75
    Quantity 10mg

    Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC50 value of 0.78 - 1.64µM and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79µM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks Kir2.1 channels (EC50 ≤ 100nM).

    • Chemical Name: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
    • Formula: C38H44O8
    • CAS Number: 2752-65-0
    • Solubility: Soluble to 75mM in DMSO and to 100mM in ethanol

  • Description & Specifications

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