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TCR gamma/delta Armenian Hamster anti-Mouse, Biotin, Clone: UC7-13D5, eBioscience™ Non-distribution product as customer accommodation.

Armenian Hamster Monoclonal Antibody

$86.50 - $279.00

Specifications

Antigen TCR gamma/delta
Clone UC7-13D5
Target Species Mouse
Conjugate Biotin
Isotype IgG
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-119-33 Non-distribution product as customer accommodation.
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Invitrogen
13581181
50 μg
Each for $86.50
Add to cart
 
50-119-34 Non-distribution product as customer accommodation.
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Invitrogen
13581182
100 μg
Each for $149.00
Add to cart
 
50-119-35 Non-distribution product as customer accommodation.
View Documents
Invitrogen
13581185
500 μg
Each for $279.00
Add to cart
 
Description

Description

Description: The UC7-13D5 monoclonal antibody reacts with the mouse gammadelta TCR complex. gammadelta TCR is expressed by a small subset of T cells in the thymus, peripheral lymphoid tissues, intestinal epithelium, and epidermis. The exact specificity, ligand and function of gammadelta TCR-bearing T cells are not yet fully understood; it is suggested that these cells recognize bacterial ligands and some tumor cells in the context of MHC class I-like gene products and play a role in regulation of the immune response and during bacterial infection. Applications Reported: UC7-13D5 has been reported for use as a phenotypic marker for gamma delta TCR-expressing T cells in flow cytometric analysis. Applications Tested: The UC7-13D5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes and can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR gamma/delta
Mouse
IgG
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
UC7-13D5
Biotin
Flow Cytometry
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.

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