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GANP Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549740

Catalog No. PA549740


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Description

Description

The antibody detects endogenous levels of total GANP / MCM3AP protein.

GANP (germinal center-associated nuclear protein) is up-regulated selectively in germinal centers and carries an MCM-binding domain in the carboxyl-terminal side. It was found that a region (from 414 to 550 aa) in GANP molecule that is slightly similar to the known DNA-primase component p49. The recombit GANP fragment covering this region synthesizes RNA primers for extension by DNA polymerase I with single-stranded DNA templates in vitro. GANP DNA-primase activity is controlled by phosphorylation at Ser(502) that is induced by CD40-mediated signaling in vitro and in the germinal center B cells stimulated with antigen in vivo. Overexpression of ganp cDNA in Daudi B cells caused the increased DNA synthesis more than the levels of the mock-transfectants. These evidences suggested that the novel DNA-primase GANP is involved in regulation of cell proliferation of antigen-driven B cells in germinal centers.
Specifications

Specifications

GANP
Polyclonal
Unconjugated
MCM3AP
Liquid
MCM3AP
Synthesized peptide derived from human GANP.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O60318, Q9WUU9
FLJ44336, FLJ45306, GANP, KIAA0572, MAP80
Rabbit
IgG
100 μL
-20°C
Primary
54387, 8888
Documents
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