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  7. GANT 61, Tocris Bioscience™

GANT 61, Tocris Bioscience™

Catalog Number 319110
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
500579-04-4
C27H35N5
429.612
KVQOGDQTWWCZFX-UHFFFAOYSA-N
gant61, gant 61, gant-61, gnt61, 2,2'-2-pyridin-4-yl dihydropyrimidine-1,3 2h,4h-diyl bis methylene bis n,n-dimethylaniline, 2-3-2-dimethylamino phenyl methyl-2-pyridin-4-yl-1,3-diazinan-1-yl methyl-n,n-dimethylaniline, ncistruc1_001747, ncistruc2_001814, 2,2'-dihydro-2-4-pyridinyl-1,3 2h,4h-pyrimidinediyl bis methylene bis n,n-dimethylbenzenamine, 2,2-2-pyridin-4-yl dihydropyrimidine-1,3 2h,4h-diyl bis methylene bis n,n-dimethylaniline
421610
2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C
This item is not returnable. View return policy
500579-04-4
C27H35N5
429.612
KVQOGDQTWWCZFX-UHFFFAOYSA-N
gant61, gant 61, gant-61, gnt61, 2,2'-2-pyridin-4-yl dihydropyrimidine-1,3 2h,4h-diyl bis methylene bis n,n-dimethylaniline, 2-3-2-dimethylamino phenyl methyl-2-pyridin-4-yl-1,3-diazinan-1-yl methyl-n,n-dimethylaniline, ncistruc1_001747, ncistruc2_001814, 2,2'-dihydro-2-4-pyridinyl-1,3 2h,4h-pyrimidinediyl bis methylene bis n,n-dimethylbenzenamine, 2,2-2-pyridin-4-yl dihydropyrimidine-1,3 2h,4h-diyl bis methylene bis n,n-dimethylaniline
421610
2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C

Description

GLI antagonist; inhibits Hedgehog (Hh) signaling

GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ∽ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.
Quantity 10 mg
Formula Weight 429.61
Percent Purity >98%
Chemical Name or Material GANT 61

Safety and Handling

Recommended Storage Store at -20°C
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