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GAPDH, Polyclonal, Bethyl Laboratories Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, IncSupplier Diversity Partner A300640AM

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Catalog No. 50-155-8104


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Zebrafish, Chicken, Turkey, Sheep, Bovine, Dog, Rabbit, Guinea pig_10141, Pig, Golden

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer ft.s disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington ft.s disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
Specifications

Specifications

GAPDH
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
P04406, P16858
Glyceraldehyde-3-Phosphate Dehydrogenase, GAPD, G3PD, G3PDH
Rabbit
IgG
100 μl
4° C
Primary
14433, 2597
Western Blot
Unconjugated
GAPDH
liquid
GAPDH
Between 200 and 250
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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