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GATA3 Rabbit anti-Human, Unconjugated, Clone: ARC0115, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535328

Catalog No. PIMA535328


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Description

Description

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
Specifications

Specifications

GATA3
ARC0115
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P23771
EGK_19445; Gata3; Gata-3; GATA-binding factor 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
2625
Western Blot
Unconjugated
GATA3
Liquid
GATA3
A synthesized peptide derived from human GATA3.
Protein A
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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