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GATM Mouse anti-Human, Clone: OTI1C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525607

Catalog No. PIMA525607


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Description

Description

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family. Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure. AGAT localizes to mitochondrial inner membranes, peripheral membranes and cytoplasm. Biallelically expressed in placenta and fetal tissues, AGAT is also expressed in brain, heart, liver, lung, salivary gland and skeletal muscle tissue, with high expression in kidney. AGAT is elevated in the myocardium during heart failure and is decreased in inter-uterine growth restriction (IUGR)-associated placenta. AGAT catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues. AGAT defects are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, severe disturbance of expressive and cognitive speech and severe depletion of creatine/phosphocreatine in brain.
Specifications

Specifications

GATM
Monoclonal
0.41 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P50440
Glycine amidinotransferase, mitochondrial; L-arginine:glycine amidinotransferaseTransamidinase; GATM; AGAT
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2628
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1C9
Unconjugated
GATM
Liquid
GATM
Full length human recombit protein of GATM produced in HEK293 cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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