GCH1 Mouse anti-Human, Clone: OTI7B8, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF810250
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThis gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
|Full length human recombit protein of human GCH1 produced in E.coli.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 8% trehalose and no preservative; pH 7.3|
|DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B|
|-20° C, Avoid Freeze/Thaw Cycles|
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