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GCH1 Mouse anti-Human, Clone: OTI8C6, liquid, TrueMAB™
Mouse Monoclonal Antibody
Supplier: OriGene TA810249
Description
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.Specifications
| GCH1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P30793 | |
| GCH1 | |
| Full length human recombit protein of human GCH1 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI8C6 | |
| Unconjugated | |
| GCH1 | |
| DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 2643 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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