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GCH1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550508

Catalog No. PA550508


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Description

Description

The antibody detects endogenous levels of total GCH1 protein.

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Specifications

Specifications

GCH1
Polyclonal
Unconjugated
GCH1
Liquid
GCH1
Synthetic peptide corresponding to a region derived from internal residues of human GTP cyclohydrolase 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
P30793
GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1
Rabbit
IgG
100 μL
-20°C
Primary
2643
Documents
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