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GCH1 Mouse anti-Human, Clone: OTI3C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527276

Catalog No. PIMA527276


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Description

Description

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Specifications

Specifications

GCH1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P30793
GCH1 ; GTP cyclohydrolase 1 (dopa-responsive dystonia) ; DYT5; GCH; GTP-CH-1; GTPCH1; GTP cyclohydrolase 1; guanosine 5′-triphosphate cyclohydrolase I
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2643
Immunohistochemistry (Paraffin), Western Blot
OTI3C9
Unconjugated
GCH1
Liquid
GCH1
Full length human recombit protein of GCH1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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