GCH1 Mouse anti-Human, Clone: OTI3C9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527276
DescriptionThis gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|GCH1 ; GTP cyclohydrolase 1 (dopa-responsive dystonia) ; DYT5; GCH; GTP-CH-1; GTPCH1; GTP cyclohydrolase 1; guanosine 5′-triphosphate cyclohydrolase I|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GCH1 produced in E.coli|
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