GCK Mouse anti-Human, Clone: OTI3E3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524929
DescriptionHexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|B lymphocyte serine/threonine protein kinase; GC kinase; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Rab8 interacting protein; b lymphocyte serine/threonine-protein kinase; germinal center kinase; germinal centre kinase (GC kinase); rab8-interacting protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)|
|Full length human recombit protein of GCK produced in HEK293T cell|
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