GCLC Mouse anti-Human, Non-human primate, Rat, Clone: OTI1A3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526346
DescriptionGlutathione (GSH) plays an important role in detoxification of oxidants and toxins from the cells. In most cells GSH is synthesized de novo in two steps catalysed by Gamma Glutamylcysteine Synthetase (GCS)/Glutamate-cystein Ligase and GSH synthetase. GCS catalyses the first and rate limiting step and is important in GSH homeostasis. It is composed of two subunits: heavy and light. These subunits are coded by different genes which are controlle by different mechanisms. The heavy subunit carries the catalytic activity and can be inhibited through feedback mechanism by GSH. Binding of light subunit to heavy subunit reduces the Michaelis-Menten constant for glutamate to a physiological concentration of 1.2mM and increases the inhibitory constant for GSH.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|GCL, GCS, GLCL, GLCLC, GCS heavy chain; gamma-ECS; gamma-glutamylcysteine synthetase; glutamate--cysteine ligase catalytic subunit|
|-20° C, Avoid Freeze/Thaw Cycles|
|25283, 2729, 710508|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GCLC produced in HEK293T cell|
|Human, Non-human primate, Rat|
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