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GCLC Mouse anti-Human, Non-human primate, Rat, Clone: OTI1A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526346

Catalog No. PIMA526346


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Description

Description

Glutathione (GSH) plays an important role in detoxification of oxidants and toxins from the cells. In most cells GSH is synthesized de novo in two steps catalysed by Gamma Glutamylcysteine Synthetase (GCS)/Glutamate-cystein Ligase and GSH synthetase. GCS catalyses the first and rate limiting step and is important in GSH homeostasis. It is composed of two subunits: heavy and light. These subunits are coded by different genes which are controlle by different mechanisms. The heavy subunit carries the catalytic activity and can be inhibited through feedback mechanism by GSH. Binding of light subunit to heavy subunit reduces the Michaelis-Menten constant for glutamate to a physiological concentration of 1.2mM and increases the inhibitory constant for GSH.
Specifications

Specifications

GCLC
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P19468, P48506
GCL, GCS, GLCL, GLCLC, GCS heavy chain; gamma-ECS; gamma-glutamylcysteine synthetase; glutamate--cysteine ligase catalytic subunit
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
25283, 2729, 710508
Immunohistochemistry (Paraffin), Western Blot
OTI1A3
Unconjugated
GCLC
Liquid
GCLC
Full length human recombit protein of GCLC produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate, Rat
Documents
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