Gemin 2 Mouse anti-Human, Clone: OTI4B3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527050
DescriptionSIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Component of gems 2;Gem (nuclear organelle) associated protein 2;Gem associated protein 2;GEMI2_HUMAN;Gemin-2;gemin2;SIP 1;SIP-1;SIP1;SIP1 delta;SIP1-delta;SMN interacting protein 1;SMN interacting protein 1 delta;SMN-interacting protein 1;Survival interacting protein 1;Survival of motor neuron protein interacting protein 1;Survival of motor neuron protein-interacting protein 1;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GEMIN2 produced in E.coli|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok