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Gemin 2 Mouse anti-Human, Clone: OTI4B3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527050

Catalog No. PIMA527050


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Description

Description

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
Specifications

Specifications

Gemin 2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O14893
Component of gems 2;Gem (nuclear organelle) associated protein 2;Gem associated protein 2;GEMI2_HUMAN;Gemin-2;gemin2;SIP 1;SIP-1;SIP1;SIP1 delta;SIP1-delta;SMN interacting protein 1;SMN interacting protein 1 delta;SMN-interacting protein 1;Survival interacting protein 1;Survival of motor neuron protein interacting protein 1;Survival of motor neuron protein-interacting protein 1;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8487
Immunohistochemistry (Paraffin), Western Blot
OTI4B3
Unconjugated
GEMIN2
Liquid
GEMIN2
Full length human recombit protein of GEMIN2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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