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GEMIN8 Monoclonal Antibody (OTI4E11), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Supplier: OriGene TA805831
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.Specifications
GEMIN8 | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q9NWZ8 | |
GEMIN8 | |
Full length human recombit protein of human GEMIN8 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI4E11 | |
Unconjugated | |
GEMIN8 | |
FAM51A1 | |
Mouse | |
Affinity Chromatography | |
RUO | |
54960 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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