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GEMIN8 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA589375

Catalog No. PIPA589375


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Description

Description

Immunogen sequence: MAAVKASTSK ATRPWYSHPV YARYWQHYHQ AMAWMQSHHN AYRKAVESCF NLPWYLPSAL LPQSSYDNEA AYPQSFYDHH VAWQDYPCSS SHFRRSGQHP RYSSRIQAST KEDQALSKEE EMETESDAEV ECDLSNMEIT EELRQYFAET ERHREERRRQ QQLDAERLDS YVNADHDLYC NTRRSVEAPT ERPGERRQAE MKRLYGDSAA KIQAMEAAVQ LSFDKHCDRK QPKYWPVIPL KF; Positive Samples: A-549, HT-29, HepG2; Cellular Location: Cytoplasm, Nucleus, gem

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GEMIN8
Polyclonal
Unconjugated
GEMIN8
B130034M20Rik, B930082C09Rik, BC023488, Fam51a1, family with sequence similarity 51, member A1, family with sequence similarity 51, member A1 homolog, gem (nuclear organelle) associated protein 8, gem nuclear organelle associated protein 8, gem-associated protein 8, GEMIN8, Gemin-8, Protein FAM51A1
Rabbit
Affinity Chromatography
RUO
54960
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.76 mg/mL
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Q9NWZ8
GEMIN8
Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human GEMIN8 (NP_0603261)
100 μL
Primary
Human
Antibody
IgG
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