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GEMIN8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548933

Catalog No. PA548933

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with bovine and mouse based on sequence homology.

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Specifications

Specifications

GEMIN8
Polyclonal
PBS with 0.09% sodium azide
Q9NWZ8
Gem-associated protein 8, Gemin-8, Protein FAM51A1, GEMIN8, FAM51A1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54960
Western Blot
Unconjugated
GEMIN8
Liquid
GEMIN8
KLH conjugated synthetic peptide between 213-239 amino acids from the C-terminal region of human GEMIN8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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