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GEMIN8 Mouse anti-Human, Clone: OTI4F8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526768

Catalog No. PIMA526768


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Description

Description

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Specifications

Specifications

GEMIN8
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NWZ8
Gem-associated protein 8, Gemin-8, Protein FAM51A1, GEMIN8, FAM51A1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54960
Immunohistochemistry (Paraffin), Western Blot
OTI4F8
Unconjugated
GEMIN8
Liquid
GEMIN8
Full length human recombit protein of GEMIN8 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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