GEN1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA587557
Immunogen sequence: LQDLPLKERI FTKLSYPQDN LQPDVNLKTL SILSVKESCI ANSGSDCTSH LSKDLPGIPL QNESRDSKIL KGDQLLQEDY KVNTSVPYSV SNTVVKTCNV RPPNTALDHS RKVDMQTTRK ILMKKSVCLD RHSSDEQSAP VFGKAKYTTQ RMKHSSQKHN SSHFKESGHN KLSSPKIHIK ETEQCVRSYE TAENEESCFP DSTKSSLSSL QCHKKENNSG TCLDSPLPLR QRLKLRFQST; Positive Samples: H460, MCF-7, Mouse thymus, Mouse spleen; Cellular Location: NucleusThis gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.
|Recombit fusion protein containing a sequence corresponding to amino acids 669-908 of human GEN1|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|
|-20° C, Avoid Freeze/Thaw Cycles|
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