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Gliotoxin, Tocris Bioscience™

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Quantity:
1 mg
This item is not returnable. View return policy
67-99-2
C13H14N2O4S2
326.385
FIVPIPIDMRVLAY-RBJBARPLSA-N
gliotoxin, aspergillin, unii-5l648ph06k, ccris 4025, gliotoxin, gladiocladium fimbriatum, gliotoxin from gliocladium fimbriatum, 10h-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-hydroxymethyl-2-methyl, gliotoxins, 3r,5as,6s,10ar-6-hydroxy-3-hydroxymethyl-2-methyl-2,3,6,10-tetrahydro-5ah-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 10h-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 2,3,5a,6-hydroxy-3-hydroxymethyl-2-methyl-, 3r-3-alpha,5a-beta,6-beta,10a-alpha
6223
CHEBI:5385
CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O
This item is not returnable. View return policy
67-99-2
C13H14N2O4S2
326.385
FIVPIPIDMRVLAY-RBJBARPLSA-N
gliotoxin, aspergillin, unii-5l648ph06k, ccris 4025, gliotoxin, gladiocladium fimbriatum, gliotoxin from gliocladium fimbriatum, 10h-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-hydroxymethyl-2-methyl, gliotoxins, 3r,5as,6s,10ar-6-hydroxy-3-hydroxymethyl-2-methyl-2,3,6,10-tetrahydro-5ah-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 10h-3,10a-epidithiopyrazino 1,2-a indole-1,4-dione, 2,3,5a,6-hydroxy-3-hydroxymethyl-2-methyl-, 3r-3-alpha,5a-beta,6-beta,10a-alpha
6223
CHEBI:5385
CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O

Description

Inhibitor of 20S proteasome; immunosuppressant

Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo.
Quantity 1 mg
Formula Weight 326.38
Percent Purity >98%
Chemical Name or Material Gliotoxin

Safety and Handling

Recommended Storage : Desiccate at -20°C

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