GLRX Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA570034

Catalog No. PIPA570034

Description

This target displays homology in the following species: Cow: 100%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 100%; Rat: 93%; Sheep: 100%

GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including human GRX1 (GLRX) and GRX2, which are members of this subfamily. Also included in this subfamily are the N-terminal GRX domains of proteins similar to human thioredoxin reductase 1 and 3.

Specifications

• Antigen: GLRX
• Classification: Polyclonal
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P10575, P12309, P35754, Q9ESH6, Q9QUH0
• Gene Symbols: GLRX
• Immunogen: synthetic peptide directed towards the middle region of human GLRX
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Equine, Guinea Pig, Human, Mouse, Ovine, Porcine, Rabbit, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: GLRX
• Gene Alias: Glrx , Glrx1 , Glutaredoxin , Glutaredoxin1 , Grx 1 , Grx1 , MGC117
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100064937, 100147797, 100344913, 100713710, 2745, 397463, 515416, 64045, 93692
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid