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GLRX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 158041AP
DescriptionGRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including human GRX1 (GLRX) and GRX2, which are members of this subfamily. Also included in this subfamily are the N-terminal GRX domains of proteins similar to human thioredoxin reductase 1 and 3.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|P35754, Q9ESH6, Q9QUH0|
|GLRX, Glutaredoxin 1, GRX, GRX1, Thioltransferase 1, TTase 1|
|2745, 64045, 93692|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|GLRX Fusion Protein Ag8535|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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