GLS2 Mouse anti-Human, Clone: OTI1C12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527165
DescriptionPhosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53 ft.s role in antioxidant defense in addition to its role in energy metabolism.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|GA, GLS, LGA, hLGA; L-glutaminase; L-glutamine amidohydrolase; breast cell glutaminase; glutaminase GA; glutaminase I; glutaminase liver isoform, mitochondrial; phosphate-activated glutaminase; phosphate-dependent glutaminase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GLS2 produced in E.coli|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok