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GLS2 Mouse anti-Human, Clone: OTI1C12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527165

Catalog No. PIMA527165


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Description

Description

Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53 ft.s role in antioxidant defense in addition to its role in energy metabolism.
Specifications

Specifications

GLS2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UI32
GA, GLS, LGA, hLGA; L-glutaminase; L-glutamine amidohydrolase; breast cell glutaminase; glutaminase GA; glutaminase I; glutaminase liver isoform, mitochondrial; phosphate-activated glutaminase; phosphate-dependent glutaminase
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
27165
Immunohistochemistry (Paraffin), Western Blot
OTI1C12
Unconjugated
GLS2
Liquid
GLS2
Full length human recombit protein of GLS2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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