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GLTSCR2/PICT1 Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS13382R

Catalog No. 50-198-2849


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Description

Description

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.
Specifications

Specifications

GLTSCR2/PICT1
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
NOP53
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
29997
NOP53
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q9NZM5
glioma tumor suppressor candidate region gene 2; Glioma tumor suppressor candidate region gene 2 protein; GLT; GLTSCR2; NOP53; p60; PICT1; PICT-1; Protein interacting with carboxyl terminus 1; Ribosome biogenesis protein NOP53
KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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