GNAS Mouse anti-Human, Clone: OTI7A4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527123
DescriptionMutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5 ft. exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5 ft. exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal domit inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described; however, their full length sequences have not been determined.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Adenylate cyclase stimulating G alpha protein;AHO;Alternative gene product encoded by XL exon;C20orf45;dJ309F20.1.1;dJ806M20.3.3;Extra large alphas protein;GNAS;GNAS complex locus;GNAS1;GPSA;Gs alpha subunit;GSA;GSP;Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1;Guanine nucleotide binding protein alpha stimulating activity polypeptide 1;Guanine nucleotide binding protein G(s) subunit alpha isoforms short;Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide regulatory protein;MGC33735;NESP;NESP55;Neuroendocrine secretory protein;PHP1A;PHP1B;PHP1C;POH;Protein ALEX;SCG6;Secretogranin VI;XLalphas;XLas;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GNAS produced in HEK293T cell|
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