Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

GNAS Mouse anti-Human, Clone: OTI7A4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527123

Catalog No. PIMA527123

Add to cart



Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5 ft. exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5 ft. exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal domit inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described; however, their full length sequences have not been determined.


1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Adenylate cyclase stimulating G alpha protein;AHO;Alternative gene product encoded by XL exon;C20orf45;dJ309F20.1.1;dJ806M20.3.3;Extra large alphas protein;GNAS;GNAS complex locus;GNAS1;GPSA;Gs alpha subunit;GSA;GSP;Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1;Guanine nucleotide binding protein alpha stimulating activity polypeptide 1;Guanine nucleotide binding protein G(s) subunit alpha isoforms short;Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide regulatory protein;MGC33735;NESP;NESP55;Neuroendocrine secretory protein;PHP1A;PHP1B;PHP1C;POH;Protein ALEX;SCG6;Secretogranin VI;XLalphas;XLas;
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Immunohistochemistry (Paraffin), Western Blot
Full length human recombit protein of GNAS produced in HEK293T cell
Affinity Chromatography
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit