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GNF 5837, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.
Specifications
Quantity | 50 mg |
Formula Weight | 535.49 |
Percent Purity | >98% |
Chemical Name or Material | GNF 5837 |
Safety and Handling
Recommended Storage | Store at +4°C |
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