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Go 6976, Tocris Bioscience™

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Quantity:
1mg
This item is not returnable. View return policy
136194-77-9
C24H18N4O
378.435
VWVYILCFSYNJHF-UHFFFAOYSA-N
unii-b9iqo7jz16,gö 6976,go 6976, solution,b9iqo7jz16,insolution gö 6976,5,6,7,13-tetrahydro-13-methyl-5-oxo-12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,12-2-cyanoethyl-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo 2,3-a pyrrolo 3,4-c carbazole,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,5,6,7,13-tetrahydro-13-methyl-5-oxo
3501
CHEBI:51913
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
This item is not returnable. View return policy
136194-77-9
C24H18N4O
378.435
VWVYILCFSYNJHF-UHFFFAOYSA-N
unii-b9iqo7jz16,gö 6976,go 6976, solution,b9iqo7jz16,insolution gö 6976,5,6,7,13-tetrahydro-13-methyl-5-oxo-12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,12-2-cyanoethyl-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo 2,3-a pyrrolo 3,4-c carbazole,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,5,6,7,13-tetrahydro-13-methyl-5-oxo
3501
CHEBI:51913
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

Description

Potent protein kinase C inhibitor; selective for α and β isozymes

Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
Quantity 1mg
Formula Weight 378.43
Percent Purity >99%
Chemical Name or Material Go 6976

Safety and Handling

Recommended Storage : Desiccate at -20°C