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Go 6976, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
1mg
This item is not returnable. View return policy
136194-77-9
C24H18N4O
378.435
VWVYILCFSYNJHF-UHFFFAOYSA-N
unii-b9iqo7jz16,gö 6976,go 6976, solution,b9iqo7jz16,insolution gö 6976,5,6,7,13-tetrahydro-13-methyl-5-oxo-12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,12-2-cyanoethyl-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo 2,3-a pyrrolo 3,4-c carbazole,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,5,6,7,13-tetrahydro-13-methyl-5-oxo
3501
CHEBI:51913
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
This item is not returnable. View return policy
136194-77-9
C24H18N4O
378.435
VWVYILCFSYNJHF-UHFFFAOYSA-N
unii-b9iqo7jz16,gö 6976,go 6976, solution,b9iqo7jz16,insolution gö 6976,5,6,7,13-tetrahydro-13-methyl-5-oxo-12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,12-2-cyanoethyl-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo 2,3-a pyrrolo 3,4-c carbazole,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo,12h-indolo 2,3-a pyrrolo 3,4-c carbazole-12-propanenitrile,5,6,7,13-tetrahydro-13-methyl-5-oxo
3501
CHEBI:51913
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

Description

Potent protein kinase C inhibitor; selective for α and β isozymes

Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.

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Quantity 1mg
Formula Weight 378.43
Percent Purity >99%
Chemical Name or Material Go 6976

Safety and Handling

Recommended Storage : Desiccate at -20°C