CST3, Goat, Polyclonal Antibody, Abnova
Goat polyclonal antibody raised against synthetic peptide of CST3.
Manufacturer: Abnova Corporation PAB12818
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeqSequence: C-SVEEEGVRRALD
|Goat polyclonal antibody raised against synthetic peptide of CST3.|
|In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)|
|Antigen affinity purification|
|ELISA, Western Blot|
|ELISA (1:8000) Western blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to amino acids at internal region of human CST3.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|16 KDa band observed in human testis and prostate lysates (calculated MW of 15.8 KDa according to NP_000090.1).|
For Research Use Only