DAG1, Goat, Polyclonal Antibody, Abnova
Goat polyclonal antibody raised against synthetic peptide of DAG1.
Manufacturer: Abnova Corporation PAB18550
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variantsSequence: C-HVGKHEYFMHATDK
|Goat polyclonal antibody raised against synthetic peptide of DAG1.|
|In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)|
|Antigen affinity purification|
|ELISA, Western Blot|
|ELISA (1:128000) Western Blot (0.2-0.6 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to amino acids at internal region of human DAG1.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Reported variants represent identical protein: NP_001159400.1, NP_004384.3.|
For Research Use Only