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DAG1, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of DAG1.

Manufacturer:  Abnova Corporation PAB18550

Catalog No. 89-120-109


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Description

Description

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants

Sequence: C-HVGKHEYFMHATDK
Specifications

Specifications

DAG1
0.5 mg/mL
Goat polyclonal antibody raised against synthetic peptide of DAG1.
In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
NP_004384.3
156DAG|A3a|AGRNR|DAG
Goat
Antigen affinity purification
RUO
Primary
1605
Human
ELISA, Western Blot
Unconjugated
ELISA (1:128000) Western Blot (0.2-0.6 ug/mL) The optimal working dilution should be determined by the end user.
DAG1
Liquid
DAG1
A synthetic peptide corresponding to amino acids at internal region of human DAG1.
100 ug
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
Reported variants represent identical protein: NP_001159400.1, NP_004384.3.
SDS
Documents
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