GP2, Mouse anti-Human, Alexa Fluor 350, Clone: GP2/1803, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP275781AF350

Catalog No. NB009178

Description

GP2 Monoclonal antibody specifically detects GP2 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

• Antigen: GP2
• Clone: GP2/1803
• Dilution: ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
• Format: Conjugated, Purified
• Gene Symbols: GP2
• Immunogen: Recombinant fragment of human GP2 protein (around aa 35-179) (exact sequence is proprietary)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

• Applications: ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Conjugate: Alexa Fluor 350
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: DKFZp779K0533, glycoprotein 2 (zymogen granule membrane), pancreatic secretory granule membrane major glycoprotein GP2, pancreatic zymogen granule membrane associated protein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75
• Host Species: Mouse
• Isotype: IgG2a Kappa
• Quantity: 0.1 mL
• Storage Requirements: Store at 4°C in the dark.
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human